The effects of saquinavir on imatinib-resistant chronic myelogenous leukemia cell lines.
نویسندگان
چکیده
We evaluated the effect of the human immunodeficiency virus (HIV) protease inhibitor saquinavir on the imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia cell lines. Saquinavir, which is also a proteasome blocker, showed dose- and time-related anti-proliferative activity, particularly on the imatinib-resistant lines and a pro-apoptotic effect. Association with imatinib caused a significant increase of activity.
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ورودعنوان ژورنال:
- Haematologica
دوره 91 5 شماره
صفحات -
تاریخ انتشار 2006